What if the drugs don’t work?

A young man has stabbed his grandmother to death in England and now faces trial. The trial is to decide whether he committed murder or manslaughter. That he killed her is not in doubt.

According to the Daily Mail, the man’s ‘addiction’ to cannabis – a usage quoted at a mere two joints daily – may be to blame. This is the grounds of his defence case, incidentally.

Buried in the article are further details that the man was also taking prescription medications – specifically Elvanse for Attention Deficit Disorder and Xanax for depression. It is reported that his mood had changed significantly in the months prior to the killing, and that his family had grown concerned about his taking both cannabis and these prescribed medicines.

Clonazepam vs. Xanax: Differences, dosage, and side effects

I don’t wish to prejudice this particular case so instead I will speak generically. Elvanse is an amphetamine stimulant. Xanax is a Benzodiazepine sedative. Anyone taking both is having their moods artificially heightened and lowered simultaneously.

Both medications have a range of significant side-effects, including hallucinations, mood swings and aggressive behaviour (Elvanse) and depression, agoraphobia, social phobia and loss of libido (Xanax).

Yes, you read that correctly. One of the side effects of a medication commonly prescribed for depression actually causes further depression. Furthermore, both drugs can cause dependence. That is, it is possible to become addicted to them. By contrast, there is no evidence that it is possible to become physiologically addicted to cannabis, though psychological dependence is widely reported.

In the 1970s, heavy sedatives like Mogadon were commonly prescribed to housewives who experienced depression or anxiety. For many of these women, this was a sentence to decades of zombification, their moods and personalities entirely suppressed under a cosh of sedation.

We now recognise that in many instances, what they were actually suffering from was social isolation, attempting to raise small children alone in dormitory suburbs without sufficient social connections and supports.

I wonder whether there might be similar societally caused reasons underpinning the vast upswing in depression, anxiety disorders and issues like ADHD among the younger generations today?

It may well be that such medications are helpful in some instances. But in many cases, people are prescribed via a ‘throwing darts at the wall’ method, where they are placed on one regimen for six months, and then if it doesn’t work, the dosage is varied or a slightly different medication offered in replacement.

As a result, they can go years without seeing their symptoms alleviate, especially as the periods of tailoring up and down on these drugs can be especially disconcerting and debilitating. Furthermore, as in the instance of the two medications mentioned, dependency issues can develop.

In such circumstances, it is hardly surprising that some young people attempt to self-medicate, especially with widely available recreational substances like cannabis. And obviously cannabis is not a good idea for a still-developing young mind, especially since it appears to catalyse the likelihood of schizophrenia and like conditions among those with genetic predispositions.

Furthermore, the THC content of cannabis has been rising for decades. The ditchweed smoked at Woodstock bears almost no resemblance to the high-octane skunk now sold in California, Amsterdam and elsewhere. When the UK newspaper the Independent reported on the dangers of skunk in 2008, reported THC content was up to 14% Nowadays, it can be as high as 25%

I have no easy answers here, but I am beginning to wonder whether future decades will look back on this era and the widespread prescription of amphetamines and barbiturates to young people, including children, with similar horror as we now look back on the decades of mothers lost in a haze of ‘mommy’s little helpers’.

Infinite Growth on a Finite Planet

Nice image from ‘Our World in Data’ here:

The last two thousand years or so (CE) make up only c. 1% of human history, but around half of all people ever have lived during that period, and one in 12 or 13 of all people ever are currently alive today.

For the record, just before humans began to farm and settle in urban environments, around 9,000 years ago, there were only around 20 million people on the entire planet. That’s the population of Cairo today.

At the time of Christ, 2,000 years ago, there was between 90 and 200 million humans on Earth. In other words, between the population of today’s Congo and today’s Nigeria.

China’s population today is around 1.48 billion. That was the population of the entire planet around 1875 CE.

When I was born, there were fewer than half the number of people alive today. Welcome to infinite growth on a finite planet. We’re getting to the point where the consequences are becoming inescapable.

Homo Sapiens is still evolving

Specifically, Europeans are still evolving, according to this recently published study by geneticists from Shanghai.

The Rise of Homo inferioris | The Genetic Link
Not all evolution is positive, of course.

So, what did they find? A whole bunch of stuff. They tested for 870 human traits in total, categorised in terms of the physical, the medical, the neurological, the behavioural and so on.

They cross-referenced their findings from contemporary European genomes against historical genomes of homo sapiens, including those from pre-neolithic hunter gatherers, early neolithic hunter gatherers, and near eastern farmers from the dawn of civilisation.

The study is dense, and it certainly helps if you are a trained geneticist, or at the very least a medical student, to read it. I am neither, but I was formerly a health correspondent, so I was able to pick out a few interesting discoveries.

Firstly, as might have been expected from the varieties of human skin tone among Europeans, this was one of the factors most prone to genetic selection over recent human history. Effectively, those in the south of Europe selected for ability to tan, while those at northerly climes selected for fairer skin. This was largely already understood to have happened.

Similarly, there is a positive selection for height. Gals have liked a tall guy throughout history, apparently. And there is also positive selection for blond and lighter hair colours, which again we could have deduced from the fact that these hair colours primarily exist among European populations.

Likewise already suspected, but perhaps less widely known, is the fact that Europeans positively selected for a predisposition to schizophrenia. It’s not clear why this is, given that schizophrenia is a debilitating mental illness. Nevertheless, the research indicates some positive selection for it, as well as, oddly enough, a predisposition towards anorexia.

Perhaps not so suspected are minor but yet statistically significant positive selections for a range of things, including raw vegetable intake and heavy alcohol drinking. Then again, Europe has a growing vegetarian and vegan population, and also tends to top the charts for excessive alcohol consumption worldwide.

The most significant evolved traits in recent history relate primarily to facial characteristics – not only hair colour but also things like nose shape and upper lip size. If this makes our ancestors seem somewhat superficial, more concerned with physical appearance than other traits, that may simply be because they are easier to immediately identify.

But much less easy to identify traits also show significant positive selection in recent times. Intelligence and insomnia have both been positively selected for in Europe in recent human history (by which I mean the past few thousand years). This makes sense of course, since it helps to be smart, and someone who stays awake at night is the first to notice nighttime dangers, but more generally this actually indicates that evolved traits go much deeper than the skin.

There’s a lot more in this study, and no doubt it will prove extremely interesting to other researchers. It certainly raises some questions, not only about the traits we have inherited from the neolithic period or our early farming history, but about the traits which seem to be subject to positive selection up to the present day.

One suspects these results can likely be extrapolated to other global populations by replicating the extensive work that went into this study. Or rather, perhaps not these exact results, but rather similar sets of results, indicating similar ongoing evolution in slightly different ways among different global populations.

It would be nice therefore to see similar studies for other global populations, in order to understand the extent to which, for example, the positive selections for schizophrenia and anorexia predisposition are universal or to what extent they’re merely European.

But the bottom line is this: we sometimes assume that recent history is not enough time for humans to have evolved much more than some few superficial variations, like skin tone. However, as this study shows, such evolved variegation is much more than skin deep, and reaches into our very behaviour and psyches.

Alternative Oxfords and the Red Atlas

I attended the Bodleian Library’s fascinating webinar on unconventional maps of Oxford on Tuesday evening, where the star turns were easily the secret Soviet maps of the city from the 1970s.

It’s a fascinating, and not fully understood story. The Soviets produced top class maps of pretty much the entire planet between the 1950s and 1980s, which remained entirely secretly and unknown to the world until the early 1990s. So good are they, that the Bodleian itself still uses some of them for reference, particularly for Turkey and Greece, apparently.

Depicted, a detail from the Red Atlas featuring Dublin city centre, from c. 1980.

No one knows entirely why the Soviets did this, especially when you couldn’t even get a map of Moscow in Moscow until the very late 1980s. I can testify that when I lived in Minsk, there were no maps available. I ended up drawing my own in a notebook just to be able to get around.

The Red Atlas probably weren’t invasion maps, but they definitely were for restricted access. All sorts of fascinating locations are carefully marked up in purple, including the usual suspects like police stations, prisons and military bases, but also places of more curious interest, such as universities.

Chicago published a selection of them a few years ago, primarily of British and American locations, and called ‘The Red Atlas’. As for the Bodleian map librarians, ownership of this is probably useful if you can read a little Russian and don’t mind your maps being about five decades out of date.

It was a little disappointing though to discover that the Bodleian’s map librarians had never heard of the map of Lyra’s Oxford, from the fiction of Philip Pullman. Clearly they aren’t familiar with his work, despite it being probably the most famous and popular of speculative geographies of the city of dreaming spires.

Their other choices of alternative Oxfords included legendary town planner Thomas Sharp‘s vision of an automobile-enabled Oxford of the post-war period, and a civil war era map which may have been deliberately inaccurate in order to throw off enemy parliamentarian forces.

But the best of the rest, secret Soviet maps apart, was the 1883 ‘Drink Map’ of Oxford, produced in a spectacular example of an own goal, by the Temperance Movement. Its reverse featured a lengthy lecture on the dangers of alcohol and the evil magistrates allegedly facilitating excessive drinking in the city, but one gets the strong feeling that, as with other such drink maps of Britain at that time, they were more likely used by thirsty people seeking a nearby locale for some fortifying adult beverages.

Nowadays, such drink maps are basically pub crawls in cartographic form. They even come in formats where one may colour in images of pubs, like a drunken infant, thereby ticking off hostelries which you have deigned to feature with your sozzled presence.

What’s the cure for conspiracy theories?

The world seems rife with conspiracy. Never before have we had a population so well educated, yet apparently so vulnerable to believing in vast conspiracy narratives. It seems like a contradiction. Researchers at UCLA have been using AI to work out how such conspiracy theories seem to emerge and subsequently collapse with ever greater velocity. But they struggle to explain why these ideas emerge at all.

The attraction of conspiracy theories is the promise that beneath the apparent chaos of the world is some underlying order and meaning, even if that meaning is negative and the order is destructive. It’s a desire to feel control, to possess agency over one’s own life.

Conspiracy theories • NPC • meme • funny • catchymemes

In an ever more individuated and atomised world, the natural human desire for bonding en masse, for submerging into a gestalt and having a sense of belonging, therefore becomes subverted by such theories. Conspiracy theories are less ideas than they are communities.

The question is not why do conspiracy theories occur. They occur because of the human need for meaning and desire for order. Nor is the question how they may be combated or defeated. They can only be challenged and overcome by implementing transparent order in society. Transparent in this sense includes the underlying principles of fairness and dignity, because people will also strive for alternate explanations when they are treated unfairly or suspect they are being stripped of their human dignity.

The question that remains about conspiracy theories is why certain narratives prosper and others do not. To an extent this is a cui bono question – who benefits? Who makes money from proliferating certain conspiracies? And certainly, there are many who make a healthy living propagating nonsense and half-baked ideas to the masses. They may even be acting in good faith, believing in the attenuated and baroque web of connections they themselves are weaving. But more significantly, it’s an issue of what cultural anxieties are exposed by conspiracy theories.

The current most prolific conspiracy theory – that shadowy cabals of elites operating both in and out of the public eye are attempting to implement population reduction and totalitarian rule – is in this sense a throwback to the unequal and undignified social structures of the laissez-faire 19th century or even earlier, to feudalism. But it also expresses very contemporary anxieties about the Covid pandemic, and deeply held suspicions about the democratic unaccountability of transnational bodies in particular, be they the EU, the IMF, the World Economic Forum or the UN.

There are, in short, no easy answers to conspiracy theories, because conspiracy theories ARE the easy answers. They satisfy the atomised citizen’s need to bond in dignity with fellow citizens and they provide a simple and moralistic order against which to resist, thereby providing meaning.

History suggests that people, no matter how well educated, will be inclined to prefer such easy moralistic explanations of the world in which they live. The attraction of such explanations is as hardwired as the desire for sugar or animal fats, and as difficult to break as a habit.

Only a world which offers its citizenry ever greater fairness and dignity, which entrusts them with agency over their own lives, has any hope of competing with the memetic addiction to conspiracy. Until such a world is in place, people will continue to believe that shadowy forces secretly rule the world and wish them harm, be they demons, or Illuminati, Elders of Zion, or psychotic men in the boardrooms of Brussels and Washington.

We don’t know them so well

I was somewhat surprised to learn this morning that one of the earliest chess world champions was a chap from Belfast called Alexander McDonnell, whose day job was lobbying in parliament on behalf of the slave owners of Guyana.

This job paid £1200 per year, the equivalent of £150,000 today, and allowed him plenty of time to practice chess when parliament wasn’t sitting. He held ownership of plantations himself, and was the author of such dubious tomes as “Considerations on Negro Slavery.”

Not a lot is known about McDonnell. There appears to be a few errors on the brief wiki page dedicated to him, including the name of his father. He was renowned as a surly and taciturn man who took up to 90 minutes per turn at the chess table, and would often later spend his evenings pacing up and down in his room replaying the games in his mind.

His opponent in his most famous match, a Frenchman called Labourdonnais, by contrast had lost all of his money in property speculation and was forced to make his living from chess. While McDonnell paced his room, the Frenchman would continue playing all-comers for a sixpence a game late into the evening, all the while fuelled by endless pints of brown ale.

Louis-Charles Mahé de La Bourdonnais - Wikipedia
Labourdonnais, no doubt looking forward to a few beers. No image of McDonnell exists.

The match was abandoned with Labourdonnais leading, when the Frenchman had to urgently return to Paris to deal with his creditors. Alas, it never resumed, because McDonnell suffered from acute kidney disease and died soon afterwards. In fact, both men died young, and are buried in graves, now lost, in Kensal Green cemetery in London. ABBA should do a musical on that match.

How Utopia may grow from Coal Black Suburbia

The best band of the Britpop era was not Blur or Oasis, nor even Pulp, but Suede.

(Shout outs to Ash, Echobelly, Sleeper and Gene too.)

So it’s been interesting reading Brett Anderson’s brief memoir, Coal Black Mornings, of the period up to the point where he became famous and his story devolves into, as he put it, “the usual ‘coke and gold discs’ memoir”.

Coal Black Mornings (English Edition) eBook : Anderson, Brett: Amazon.it:  Kindle Store

Comparing it to David Mitchell’s novel Utopia Avenue, which features a fictional band from the Sixties, it’s interesting to see the many overlaps. The early sections of Utopia Avenue are easily the most interesting.

Both are tales of three-bar fires, poky terrace houses, distant parents, and the edgy tedium of suburbia, all opening up into a London which is equated to liberty, albeit a grimy, pot-infused, impoverished kind of freedom.

The conclusion of Mitchell’s novel, bar one not-especially-shocking twist, devolves to the same hotel rooms, drugs and hangers-on narrative one can find in any rock or pop memoir. One suspects Mitchell had nowhere else to go.

One also wonders whence he derived where the novel came from. Anderson’s origins are far from unique (mine shares many of the same attributes, albeit with the added frisson of a low-level civil war going on at the edge of the stage). But I wonder whether Mitchell read Anderson’s book before completing his own?

More memoirists should consider Anderson’s approach rather than speeding through their childhoods to get to the fame bits. Fame is boring and monotonous, and judging by the opinions of the occasional famous person I’ve met, somewhat of a trap and a burden. We are made by our youth and it is there where we may be found.

Thanks to the success of this first volume, Anderson wrote a follow-up about his fame years. It gets pretty good reviews, but as with the latter portion of Mitchell’s novel, I suspect it might disappoint, so I intend to leave his story hanging, perpetually suspended on the brink of success.

We are all Ukraine, and that’s not a good thing to be

When I was a journalist, I used to embody the maxim from James Joyce’s Ulysses that ‘sufficient unto the day is the newspaper thereof’. Or, to use an almost equally antiquated saying, today’s news wraps tomorrow’s chips.

In other words, it’s kind of a foolish enterprise to pontificate (as I am about to do) on matters which are kinetic. Tomorrow, next month, in one hour, the situation will change, radically. One’s assumptions, presumptions and conclusions are at best provisional and likely to become hostages to fortune very quickly.

An additional relevant point is that I’m not any expert on Ukraine. I’ve never been there. I’m not Ukrainian. Of course those attributes haven’t stopped others from spouting their tupennyworth of verbiage, so why should I be shy? At least my lack of knowledge doesn’t feed into the principals in this scenario. I’m not advising world leaders or directing the opinion of nations.

Ordinarily, I’d be silent, on the basis that when one is silent people may only presume you are an idiot, without you providing the incontrovertible proof thereof. But the current crisis in the Ukraine shows a risk of spreading, virus-like, to affect the rest of the planet, and I live here too, so on this occasion I’m prepared to take the risk. I will attempt to be brief, hence the bullet point format.

Crisi Ucraina, donne e bambini in fuga dal Donbass e i leader avvertono:  “Mobilitazione generale” - Il Riformista
  1. The Ukraine is seen by Russia at their sphere of influence. Specifically the Eastern provinces are highly culturally Russian. The Kiev government has not been keen to accommodate this and has banned teaching in Russian in schools, and all discussion about reconsidering Ukraine’s borders. One presumes this Russophobia is a reaction to the occupation/annexation/secessation of the Crimea. Nevertheless, it means that Ukraine, in its current form, is unlikely to be preserved.
  2. NATO did promise, under Bush, not to expand to Russia’s borders, then did exactly that, repeatedly in the Baltic states. Russia is not pleased about this and has attempted to address it in a number of ways. Both Yeltsin and Putin actually applied to join NATO, and were turned down, because of course NATO’s creation and existence is in opposition to Russia. This means that Russia is aggrieved. It doesn’t make them the victims of the current situation, far from it, but that situation derives from the former.
  3. Beyond both the debatable legitimacy of the USA (or indeed NATO or the EU) involving themselves in the Ukraine arena, and the clear unpopularity among the American people for another foreign war, especially one with Russia, there’s the fact that Washington got completely blindsided by Putin this time. They clearly didn’t foresee that he would endorse the kind of colour revolution which the US has been tacitly and overtly supporting in a range of locations. He’s played them at their own game, and they weren’t prepared for that.
  4. This situation is DANGEROUS and fundamentally destabilising to global geopolitics. Already the Baltic states are nervous. But they’re always nervous. More concerning for Moscow is the issue of the US locating missile launch sites in Poland, ostensibly aimed at Tehran but tacitly able to reach Moscow in minutes. One might argue this in turn is a reaction to Russian nukes in Kaliningrad, pointing towards Europe. But what we need is a DE-ESCALATION not an escalation of threat.
  5. What happens in the Ukraine will have knock-on effects across the planet. Not just the possibility that Europe, which receives over 40% of its heating gas from Russia, will freeze, but also massive touchpaper issues like Taiwan. Washington and NATO have positioned themselves such that they must implement serious reaction, as they’ve repeatedly threatened, if they deem that Putin has indeed invaded Ukraine. Putin has already been driven into restoring the old alliance with China, and China will be watching avidly to see how Washington responds to Donbass. There are contradictory precedents all around, and we will no doubt hear of them all. But if NATO/US do NOT react to Putin’s colour revolution in Donbass, China will definitely be emboldened in relation to Taiwan. But if they DO react, these are nuclear powers we’re talking about. The world itself becomes at risk.
  6. As is ALWAYS the case when war-war looms large, what we need is more jaw-jaw. It’s time to talk, with everything on the table. Maybe we need to commission a conference to redraw some borders in Eastern Europe. Maybe we need to stop backing Russia into a corner and into the arms of Xi and China.
  7. Maybe we need to consider what a ‘world beyond five’ might look like seriously. Maybe it’s time to discuss taking nukes off the table for good, from EVERYONE, including other hotheads like India and Pakistan, and, yes, Israel too. Everyone. Maybe it’s time for cool heads to prevail. Am I confident this will happen? Not really, no. But this is another Cuban Missile Crisis, taking place this time when we are ALREADY at a mere 100 seconds to midnight on the doomsday clock, and when global co-operation is needed as it has never been needed before, to address existential risks to us all, like the climate crisis.
  8. Ukraine is under threat tonight (maybe not tomorrow hopefully, but tonight, yes). And we are ALL Ukraine. We are all at risk. It’s time to sideline the sabre-rattling media, the warmongering neocons in Washington, the bored Russian generals, and the neo-Nazi militias in Ukraine and get the grown-ups talking. To do otherwise is potentially suicidal.

Post-Script: It’s always beneficial to recall Field Marshall Montgomery’s rules of military strategy, iterated here in the NYT during the Vietnam War: “The United States has broken the second rule of war. That is: don’t go fighting with your land army on the mainland in Asia. Rule One is, don’t march on Moscow. I developed those two rules myself.” (New York Times, July 3, 1968.)

Molloy and Malone, Magee and Muldoon

I saw an old photograph of the road where my house is recently. It dated from sometime in the early 20th century, and featured a horsedrawn hearse with four formally-dressed funeral directors smoking while waiting outside a church for the funeral service to end. It captivated me, the life-in-death-in-life of it. Alas, I can no longer find it on the interwebs, but it evoked an era possibly contemporaneous with this one, from 1914.

Picture taken from a gallery posted online by BelfastLive.

Anyhow, it inspired a bit of verse, written for no good reason in an approximation of iambic pentameter.

Molloy and Malone, Magee and Muldoon


Molloy and Malone, Magee and Muldoon

Wait by the roadside, Tuesday afore noon,

Outside the wee redbrick church that was built

With money raised from parishioner guilt.


Magee and Muldoon, Molloy and Malone

Come from the New Lodge, the Ardoyne, the Bone

To bury, when time comes around at last,

The dearly departed of all North Belfast.


Muldoon and Molloy, Malone and Magee,

Smoking in black suits of conformity,

Won’t darken the door of the chapel at all.

They prefer the bar, or the grey snooker hall.


Malone and Magee, Muldoon and Molloy,

Scowl at the sunshine which they can’t enjoy.

Theirs is the burden and theirs is the curse

To hoist us on their shoulders and into the hearse

Talking Turkey about Hyperinflation

The British currency, the pound sterling, takes its name from the fact that, when it first issued, it was redeemable for a pound of silver. That was somewhen in the late 8th century Anglo-Saxon period.

If we do the maths, based on today’s silver spot price, that means that the pound today is worth approximately 1/210th of what it was worth nearly 13 centuries ago.By contrast, the French managed to devalue their currency by more in just 18 months during the early 1790s, as did Germany in less than a year during the Weimar period.

The worst affected ever were the poor Hungarians in the immediate post-war period in 1945. They suffered that level of devaluation in under 6 days at peak. Armenia, Zimbabwe and Argentina have experienced similar horrors.

Tour di 2 giorni in Cappadocia da Side
Beautiful country, beautiful people, ugly economic policies.

Why do I mention this? Because it still happens today. Last semester, in Turkey, I saw my wages collapse by more than half in two months. My colleagues there are still living through this. They suffer daily price hikes in fuel and food costs, with static wages. The Turkish people, like the Armenians, Zimbabweans, Argentinians, or the Hungarians, Germans and French of former times, have done nothing wrong. But they were the ones to suffer.

Hyperinflation is caused by only one thing – shitty governments implementing shitty policies. It destroys savings, commerce, and most importantly, lives. We don’t always think too much about Turkey in the West, but we should. Here is a country suffering a preposterously stupid government and massive devaluation of their economy, yet still accommodates 3.6 MILLION refugees.

It was a salutory lesson for me in macro-economics, and in human decency, to spend last semester in Turkey. My heart remains with them in their plight, and I hope to see them in better times soon. It is a beautiful nation with a beautiful people who deserve better.

A caveat: I am not, never have been and never will be an economist. But it doesn’t take a Harvard MBA to understand money.